M. leprae typing by genomic diversity of clinical isolates in Korea / 나학회지
Korean Leprosy Bulletin
;
: 3-24, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-22152
ABSTRACT
Recently, PCR-based typing would be of great value for Epidemiological investigation to identify infectious source of leprosy, understand transmission pattern, and distinguish between relapse & re-infection. Variable TTC DNA repeats in non-coding region and 6bp(GACATC) tandem repeats in rpoT gene revealed PCR products of different size may be useful to investigate the epidemiology of leprosy. Authors have typed clinical isolates of M. leprae in Korea using difference of TTC DNA repeats in non-coding region and 6bp(ACATCG) tandem repeats in rpoT gene. Of the sequence analysis of isolates(M. leprae) of 52 patients(44 Koreans, 8 foreigners; Bangladesh, Indonesia, Philippine, Sri Lanka, Thailand) M. leprae with 12 TTC repeats was showed most common(13 cases, 29.5%) in 44 Korean isolates and 42 Koreans(95.5% of Korean isolates) isolates demonstrated four copies of 6bp(ACATCG) tandem repeats in rpoT gene and the isolates with three copies were found in 2 Koreans and 8 foreigners.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Sri Lanka
/
Bangladesh
/
DNA
/
Reação em Cadeia da Polimerase
/
Epidemiologia
/
Análise de Sequência
/
Sequências de Repetição em Tandem
/
Emigrantes e Imigrantes
/
Indonésia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Leprosy Bulletin
Ano de publicação:
2007
Tipo de documento:
Artigo
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