Prognostic significance of neutropenia during adjuvant concurrent chemoradiotherapy in early cervical cancer / 부인종양
Journal of Gynecologic Oncology
;
: 146-150, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-221571
ABSTRACT
OBJECTIVE:
To evaluate the prognostic significance of adjuvant concurrent chemoradiotherapy-induced neutropenia with survival in patients with squamous cell carcinoma of the uterine cervix.METHODS:
Data from 107 patients with stage IB-IIB cervical cancer were retrospectively analyzed. The median follow-up was 37.5 (4.2-72.7) months. All patients had received radical surgery, including pelvic lymphadenectomy, followed by paclitaxel plus carboplatin-based concurrent chemoradiotherapy. Relative neutropenia, defined as an absolute neutrophil count <1,000/mm3 at the concurrent chemoradiotherapy cycle nadir, correlated to the pathologic findings and survival outcomes.RESULTS:
Sixty-six patients experienced neutropenia at least once during concurrent chemoradiotherapy, and demonstrated marginal improvement in disease-free survival (p=0.055), although not in overall survival. By subgroup analyses, the gain of disease free survival mainly originated from the node metastasis subgroup (p=0.033). Treatment-induced neutropenia proved to be the only significant independent factor for recurrence in cervical cancer (p=0.042) by multivariate analysis.CONCLUSION:
Concurrent chemoradiotherapy-induced neutropenia may be a prognostic factor of recurrence in patients with cervical cancer. Individualized dose titration of the tolerable myelosuppression might be beneficial.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Carcinoma de Células Escamosas
/
Neoplasias do Colo do Útero
/
Colo do Útero
/
Análise Multivariada
/
Estudos Retrospectivos
/
Seguimentos
/
Paclitaxel
/
Intervalo Livre de Doença
/
Quimiorradioterapia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2009
Tipo de documento:
Artigo
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