Autoimmune Neuropsychiatric Disorder and Tic Symptom Exacerbation in Tourette's Disorder: Comparision of Treatment Modalities / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 1204-1213, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-221970
ABSTRACT
OBJECT The purpose of this study was to investigate that infection with group A[beta] hemolytic streptococcus may associate the mechanisms that cause or exacerbate some cases of Tourette's disorder and to evaluate the treatment effect of IG therapy, comparing between IG therapy and drug therapy. METHOD:
The subjects were divided into three groups composing of the groups with increasing level of ASO titer and the group with normal level of ASO titer, treating with antipsychotics. Children with infection-triggered exacerbation of Tourette's disorder were assigned treatment with IVIG (400mg/kg/daily on 5 consecutive days) or antipsychotic drugs. Symptom severity was rated at baseline, and at 4weeks, at at 8weeks after treatment by use of standard assessment scale of tics.RESULTS:
1) The motor tic score, global severity scores and overall TS impairment rating scores of YGTSS in the group with incresing level of ASO titer were related with ASO titer. 2) Immune therapy was more effective in the group with incresing level of ASO titer than antipsychotic drug therapy.CONCLUSION:
These results suggest that increasing level of ASO titer, resulting from group A[beta] hemolytic streptococcal infection has affected worsening the tic symptoms in Touette's disorder and in group with increasing level of ASO titer, IVIG therapy is more effective than drug therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infecções Estreptocócicas
/
Streptococcus
/
Antipsicóticos
/
Síndrome de Tourette
/
Imunoglobulinas Intravenosas
/
Tiques
/
Tratamento Farmacológico
Tipo de estudo:
Estudo diagnóstico
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
2001
Tipo de documento:
Artigo
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