Non-invasive prenatal diagnosis of fetal trisomy 21 using cell-free fetal DNA in maternal blood
Obstetrics & Gynecology Science
;
: 58-66, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-22221
ABSTRACT
Since the existence of cell-free fetal DNA (cff-DNA) in maternal circulation was discovered, it has been identified as a promising source of fetal genetic material in the development of reliable methods for non-invasive prenatal diagnosis (NIPD) of fetal trisomy 21 (T21). Currently, a prenatal diagnosis of fetal T21 is achieved through invasive techniques, such as chorionic villus sampling or amniocentesis. However, such invasive diagnostic tests are expensive, require expert technicians, and have a miscarriage risk approximately 1%. Therefore, NIPD using cff-DNA in the detection of fetal T21 is significant in prenatal care. Recently, the application of new techniques using single-molecular counting methods and the development of fetal-specific epigenetic markers has opened up new possibilities in the NIPD of fetal T21 using cff-DNA. These new technologies will facilitate safer, more sensitive and accurate prenatal tests in the near future. In this review, we investigate the recent methods for the NIPD of fetal T21 and discuss their implications in future clinical practice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cuidado Pré-Natal
/
Diagnóstico Pré-Natal
/
Trissomia
/
DNA
/
Amostra da Vilosidade Coriônica
/
Aborto Espontâneo
/
Síndrome de Down
/
Testes Diagnósticos de Rotina
/
Epigenômica
/
Amniocentese
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Obstetrics & Gynecology Science
Ano de publicação:
2013
Tipo de documento:
Artigo
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