Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea
Journal of Menopausal Medicine
; : 69-73, 2017.
Article
em En
| WPRIM
| ID: wpr-222375
Biblioteca responsável:
WPRO
ABSTRACT
We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c. 3261dupC).
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Imuno-Histoquímica
/
Neoplasias Colorretais Hereditárias sem Polipose
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Neoplasias do Endométrio
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Colo
/
Neoplasias do Colo
/
Mutação em Linhagem Germinativa
/
Irmãos
/
Aconselhamento Genético
/
Coreia (Geográfico)
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Menopausal Medicine
Ano de publicação:
2017
Tipo de documento:
Article