Combination Therapy of Raloxifene and Alendronate for Treatment of Osteoporosis in Elderly Women
Journal of Menopausal Medicine
;
: 56-62, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-222377
ABSTRACT
OBJECTIVES:
To evaluate and compare the efficacy and safety of the combination of raloxifene and alendronate with those of monotherapies in elderly women with osteoporosis.METHODS:
Sixty-two postmenopausal women (mean age 63.5 ± 0.5 years) attending gynecologic osteoporosis clinics with established osteoporosis were randomly allocated to one of four treatment groups and monitored for 3 years. All patients enrolled in this study, including those in the control group (n = 14), received 1.0 g elemental calcium and 400 units of vitamin D per day. The raloxifene group (n = 16) received raloxifene 60 mg (Evista®) per day; alendronate group (n = 17) received low-dose (5 mg) alendronate with calcitriol 0.5 µg (Maxmarvil®) per day; and the combination therapy group (n = 15) received both raloxifene 60 mg and low-dose (5 mg) alendronate with calcitriol 0.5 µg. Bone mineral density (BMD) was measured in the lumbar spine and hip before and after 3 years of treatment.RESULTS:
In patients who received the combined therapy, BMD increased in the lumbar spine and the hip by 7.2% (P<0.001) and 4.8% (P<0.001) at 3 years. For patients in the alendronate group, the increases were 6.7% (P<0.001) and 3.1% (P<0.01) respectively, for the raloxifene group, the increases were 4.36% (P<0.001) and 1.9% (P<0.05) in the vertebrae and femora, respectively; however, the BMD of patients in the control group decreased by 1.81% (P<0.05) and 1.6% (P<0.05), respectively, after 3 years. Patients who received the combination therapy had significantly higher BMD in both the vertebrae femora (P<0.01) in comparison to that in those treated with raloxifene or alendronate individually.CONCLUSIONS:
This 3-year randomized study showed the improved effects of alendronate and raloxifene combination on spine and hip BMD in elderly postmenopausal women with established osteoporosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoporose
/
Coluna Vertebral
/
Vitamina D
/
Calcitriol
/
Densidade Óssea
/
Cálcio
/
Alendronato
/
Cloridrato de Raloxifeno
/
Quadril
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Menopausal Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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