Exenatide versus Insulin Lispro Added to Basal Insulin in a Subgroup of Korean Patients with Type 2 Diabetes Mellitus
Diabetes & Metabolism Journal
;
: 69-74, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-222880
ABSTRACT
BACKGROUND:
The prevalence of type 2 diabetes mellitus (T2DM) and obesity is increasing in Korea. Clinical studies in patients with T2DM have shown that combining the glucagon-like peptide-1 receptor agonist exenatide twice daily with basal insulin is an effective glucose-lowering strategy. However, these studies were predominantly conducted in non-Asian populations.METHODS:
We conducted a subgroup analysis of data from a multinational, 30-week, randomized, open-label trial to compare the effects of exenatide twice daily (n=10) or three times daily mealtime insulin lispro (n=13) among Korean patients with T2DM inadequately controlled (glycosylated hemoglobin [HbA1c] >7.0%) on metformin plus optimized insulin glargine.RESULTS:
Exenatide twice daily and insulin lispro both reduced HbA1c (mean −1.5% and −1.0%, respectively; P<0.01 vs. baseline). Fasting glucose and weight numerically decreased with exenatide twice daily (−0.7 mmol/L and −0.7 kg, respectively) and numerically increased with insulin lispro (0.9 mmol/L and 1.0 kg, respectively). Minor hypoglycemia occurred in four patients receiving exenatide twice daily and three patients receiving insulin lispro. Gastrointestinal adverse events were the most common with exenatide twice daily treatment.CONCLUSION:
This analysis found treatment with exenatide twice daily improved glycemic control without weight gain in Korean patients with T2DM unable to achieve glycemic control on metformin plus basal insulin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aumento de Peso
/
Prevalência
/
Jejum
/
Diabetes Mellitus Tipo 2
/
Insulina Lispro
/
Refeições
/
Insulina Glargina
/
Receptor do Peptídeo Semelhante ao Glucagon 1
/
Glucose
/
Hipoglicemia
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de prevalência
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
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