Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats / 한국실험동물학회지
Laboratory Animal Research
;
: 225-232, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-223292
ABSTRACT
Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medula Espinal
/
Traumatismos da Medula Espinal
/
Células do Corno Posterior
/
Discriminação Psicológica
/
Sensibilização do Sistema Nervoso Central
/
Neuralgia
/
Neurônios
Limite:
Animais
Idioma:
Coreano
Revista:
Laboratory Animal Research
Ano de publicação:
2010
Tipo de documento:
Artigo
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