Effect of An Allergic Contact Dermatitis on the Irritant Response in Guinea Pigs / 대한피부과학회지
Korean Journal of Dermatology
;
: 446-450, 1987.
Artigo
em Coreano
| WPRIM
| ID: wpr-223520
ABSTRACT
The effect of an allergic contact dermatitis on the irritant was studied using DNCB(2. 5% in acetone) as the sensitizing agent and sodium lauryl sulfate of various concentrations (0. 5, 1. 0, 2. 0% in Vaseline) as the irritant. Three groups of 30 albino Hartley strain female guinea pigs weighing between 350 g and 500 g were used. The results were as follows 1. The animals which were sensitized with DNCB were shown to be significantly(p<0.05) more irritable than control animals. 2. The animals which were sensitized and challenged with DNCB were shown to be significantly(p<0. 05) more irritable than control and sensitized animals. These data suggest that allergic contact sensitivity as well as allergic contact dermatitis lower the threshold to a nonspecific irritant in guinea pigs, which may explain a mechanism of 'angry back syndrome.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dodecilsulfato de Sódio
/
Guiné
/
Dermatite Alérgica de Contato
/
Dermatite de Contato
/
Dinitroclorobenzeno
/
Cobaias
Limite:
Animais
/
Feminino
/
Humanos
País/Região como assunto:
África
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1987
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS