Correlation Between Apoptosis and Intratumoral Microvessel Density in Non-Small Cell Lung Cancer / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 151-157, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-223595
ABSTRACT
BACKGROUND:
Increasing evidences from experimental studies indicate that apoptosis may be inversely related to angiogenesis in tumor progression. MATERIAL ANDMETHOD:
To explore how apoptosis correlates with tumor angiogenesis, we measured the apoptotic index(AI) using the terminal deoxynucleotidyl transferase method(Apop Tag In Situ Apoptosis Detection Kit, ONCOR) and the intratumoral microvessel density using the anti-CD31 monoclonal antibody in non-small cell lung cancer.RESULT:
Statistical analysis revealed an inverse correlation between AIs and intratumoral microvessel densities in squamous cell lung carcinoma(Spearman rank correlation coefficient r=- 0.229, p=0.047).CONCLUSION:
The results of this study demonstrated that the amount of apoptosis in squamous cell lung carcinoma may be influenced by the extent of neovascularization. This suggests that tumor angiogenesis may contribute to a reduction of apoptosis in tumor cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apoptose
/
Carcinoma Pulmonar de Células não Pequenas
/
DNA Nucleotidilexotransferase
/
Microvasos
/
Pulmão
/
Neoplasias Pulmonares
Idioma:
Coreano
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
1999
Tipo de documento:
Artigo
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