Relationship between spontaneous preterm birth and polymorphisms of Interleukin-1beta and Interleukin-1 receptor antagonist in Korean women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 85-92, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-224174
ABSTRACT
OBJECTIVE:
Preterm birth is an important cause of infant death and morbidity but its pathophysiology still remains to be clear. The associations between preterm birth and the polymorphism of interleukin-1beta gene and interleukin-1 receptor antagonist gene have been suspected. And ethnic variations in the polymorphism of the genes were also reported. We decided to study polymorphisms of interleukin-1beta+3953 and interleukin-1 receptor antagonist in Korean pregnant women.METHODS:
Patients were divided into 2 groups. Group 1 is the control group of 33 subjects with uncomplicated term delivery group 2 is the case group of patients who had spontaneous preterm delivery. Polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism analysis.RESULTS:
There were significant differences in gestational age and birth weight between two groups (P<0.001). No significant differences were found in genotypic frequencies and allelic frequencies in interleukin-1beta+3953 between two groups. Interleukin-1 receptor antagonist gene had 5 alleles and the most frequent allele was IL1RN*1 (410bp), 66.7% in control group and 77.8% in case group. And significant differences were not found in genotypic frequencies and allelic frequencies between two groups, too.CONCLUSION:
There were no significant differences in polymorphisms in interleukin-1beta +3953 and interleukin-1 receptor antagonist between term delivery group and preterm birth group.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peso ao Nascer
/
Polimorfismo de Fragmento de Restrição
/
Reação em Cadeia da Polimerase
/
Idade Gestacional
/
Interleucina-1
/
Gestantes
/
Nascimento Prematuro
/
Alelos
/
Interleucina-1beta
Limite:
Feminino
/
Humanos
/
Lactente
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2007
Tipo de documento:
Artigo
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