Comparative Vestibulotoxicity of Different Aminoglycosides in the Guinea Pigs
Yonsei Medical Journal
;
: 517-522, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-224217
ABSTRACT
The histopathological alterations in the vestibule due to aminoglycosides are well defined. Although there are reports comparing the vestibulotoxic effects of the many aminoglycosides, this is the first study to compare the effects of the most commonly used aminoglycosides i.e., streptomycin, gentamicin, amikacin and netilmicin administered both transtympanically and systemically. The transtympanic and systemic administration of each aminoglycoside caused similar histopathological alterations in the vestibule. The most severe degeneration in the cristae ampullaris, utriculus and sacculus was observed after streptomycine administration. The severity of the vestibular damage in terms of magnitude was in the order of streptomycine, gentamicin, amikacin, and netilmicin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Membrana Timpânica
/
Estudo Comparativo
/
Amicacina
/
Gentamicinas
/
Netilmicina
/
Estreptomicina
/
Vestíbulo do Labirinto
/
Cobaias
/
Injeções Intraperitoneais
Limite:
Animais
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo
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