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Fatty liver associated with metabolic derangement in patients with chronic kidney disease: A controlled attenuation parameter study
Kidney Research and Clinical Practice ; : 48-57, 2017.
Artigo em Inglês | WPRIM | ID: wpr-224474
ABSTRACT

BACKGROUND:

Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients.

METHODS:

CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years).

RESULTS:

The median CAP value was 239 (202–274) dB/m. In 195 (41.9%) patients with metabolic syndrome, diabetes mellitus was more prevalent (105 [53.8%] vs. 71 [26.3%], P < 0.001), with significantly increased urine albumin-to-creatinine ratio (184 [38–706] vs. 56 [16–408] mg/g Cr, P = 0.003), high sensitivity C-reactive protein levels (5.4 [1.4–28.2] vs. 1.7 [0.6–9.9] mg/L, P < 0.001), and CAP (248 [210–302] vs. 226 [196–259] dB/m, P < 0.001). In multiple linear regression analysis, CAP was independently related to body mass index (β = 0.742, P < 0.001), triglyceride levels (β = 2.034, P < 0.001), estimated glomerular filtration rate (β = 0.316, P = 0.001), serum albumin (β = 1.386, P < 0.001), alanine aminotransferase (β = 0.064, P = 0.029), and total bilirubin (β = −0.881, P = 0.009). In multiple logistic regression analysis, increased CAP was independently associated with increased metabolic syndrome risk (per 10 dB/m increase; odds ratio, 1.093; 95% confidence interval, 1.009–1.183; P = 0.029) even after adjusting for multiple confounding factors.

CONCLUSION:

Increased CAP measured with transient elastography significantly correlated with and could predict increased metabolic syndrome risk in chronic kidney disease patients.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Triglicerídeos / Bilirrubina / Proteína C-Reativa / Albumina Sérica / Índice de Massa Corporal / Modelos Lineares / Modelos Logísticos / Razão de Chances / Diabetes Mellitus / Alanina Transaminase Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Triglicerídeos / Bilirrubina / Proteína C-Reativa / Albumina Sérica / Índice de Massa Corporal / Modelos Lineares / Modelos Logísticos / Razão de Chances / Diabetes Mellitus / Alanina Transaminase Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2017 Tipo de documento: Artigo