Heterologous corneal endothelial cell transplantation: human corneal endothelial cell transplantation in Lewis rats
Journal of Korean Medical Science
;
: 337-342, 1992.
Artigo
em Inglês
| WPRIM
| ID: wpr-224506
ABSTRACT
A heterologous corneal endothelial transplantation was attempted using human endothelial cells and a Lewis rat penetrating keratoplasty model. Cultured human endothelial cells were seeded to a Lewis rat cornea, which was denuded of its endothelium. When grafted into the syngeneic Lewis rat, the graft remained clear for at least five days, and then became opaque and edematous because of immune rejection reaction. In contrast, corneas denuded of their endothelium became opaque and edematous immediately after transplantation. These results demonstrate that transplanted endothelial cells have enough antigens to induce rejection reaction even though they have the functional capacity to deturge the cornea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ratos Endogâmicos Lew
/
Transplante Heterólogo
/
Endotélio Corneano
/
Rejeição de Enxerto
/
Complexo Principal de Histocompatibilidade
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
1992
Tipo de documento:
Artigo
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