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A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia / 대한내과학회지
Korean Journal of Medicine ; : 386-390, 2010.
Artigo em Coreano | WPRIM | ID: wpr-224540
ABSTRACT
Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piperazinas / Pirimidinas / Trombocitose / Benzamidas / Medula Óssea / Receptores do Fator de Crescimento Derivado de Plaquetas / Hibridização In Situ / Tosse / Receptor beta de Fator de Crescimento Derivado de Plaquetas / Eosinofilia Limite: Idoso / Aged80 / Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piperazinas / Pirimidinas / Trombocitose / Benzamidas / Medula Óssea / Receptores do Fator de Crescimento Derivado de Plaquetas / Hibridização In Situ / Tosse / Receptor beta de Fator de Crescimento Derivado de Plaquetas / Eosinofilia Limite: Idoso / Aged80 / Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2010 Tipo de documento: Artigo