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Effect of Fenofibrate Therapy on Blood Creatinine Levels in Patients with Hypertension and Hypertriglyceridemia
Journal of Lipid and Atherosclerosis ; : 19-26, 2013.
Artigo em Coreano | WPRIM | ID: wpr-225318
ABSTRACT

OBJECTIVE:

Previous studies have reported that fenofibrate therapy increased blood creatinine levels. We investigated the effect of fenofibrate therapy on creatinine levels in patients with hypertension and hypertriglyceridemia.

METHODS:

This retrospective study included 36 hypertensive patients with hypertriglyceridemia taking fenofibrate for 1-3 years (Fenofibrate group) and 36 control patients with similar age, sex, follow-up duration, creatinine levels, and lipid levels to those of fenofibrate therapy (Control group).

RESULTS:

Baseline parameters except lipid profiles were similar between the fenofibrate and control groups. Creatinine levels increased in the fenofibrate group (from 0.90+/-0.18 mg/dL to 1.05+/-0.22 mg/dL, p<0.001) and did not change in the control group (from 0.91+/-0.12 mg/dL to 0.92+/-0.14 mg/dL, p=0.39). The elevation was more pronounced in the fenofibrate group than in the control group (0.15+/-0.12 vs. 0.02+/-0.11 mg/dL, p<0.001). Changes in creatinine levels were only associated with fenofibrate therapy (r=0.52, p<0.001) in the stepwise linear regression analysis.

CONCLUSION:

Fenofibrate therapy for 1-3 years significantly increased creatinine levels in hypertensive patients with hypertriglyceridemia. This finding suggests that follow-up measurement of creatinine level is necessary with fenofibrate therapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenofibrato / Hipertrigliceridemia / Modelos Lineares / Estudos Retrospectivos / Seguimentos / Creatinina / Hipertensão Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Coreano Revista: Journal of Lipid and Atherosclerosis Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenofibrato / Hipertrigliceridemia / Modelos Lineares / Estudos Retrospectivos / Seguimentos / Creatinina / Hipertensão Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Coreano Revista: Journal of Lipid and Atherosclerosis Ano de publicação: 2013 Tipo de documento: Artigo