Soluble E-selectin as A Clinical Marker of Disease Activity in Atopic Dermatitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 222-230, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-225329
ABSTRACT
PURPOSE:
Augmentation in the expression of E-selectin on activated vascular endothelial cells regulates leukocyte migration into the tissue. These molecules are also shed into the circulation as a soluble form. The level of soluble forms in the serum has been known to be correlated with those expressed on the endothelial cells, thus it can be used as a marker of inflammation in that tissue. The purpose of this study is to compare the serum levels of soluble E-selectin(sE-selectin) in patients with atopic dermatitis(AD), atopic asthmatics, and healthy non-atopics, and to determine whether sE-selectin levels are correlated with disease activity in patients with atopic dermatitis.METHODS:
We examined serum sE-selectin levels, serum total IgE levels, and total eosinophil counts from 18 children with AD, 15 atopic asthmatics and 15 healthy non-atopics. The severity of AD was assessed by clinical scoring(SCORAD index). We compared the sE-selectin levels among the three groups and investigated the correlations with SCORAD index.RESULTS:
The children with AD had significantly higher levels of sE-selectin than those of atopic asthmatics(P<0.05) and of healthy non-atopics(P<0.05). There was no difference in the serum sE-selectin levels between the groups of atopic asthmatics and healthy non- atopics. Serum sE-selectin levels were correlated with SCORAD index in patients with AD, (P<0.05) but not significantly correlated with serum total IgE levels and total eosinophil counts. There were no significant correlations among SCORAD index, serum total IgE levels, and total eosinophil counts.CONCLUSION:
The serum sE-selectin level is elevated only in patients with AD, not in atopic asthmatics. Therefore, sE-selectin could be considered as a useful marker of the disease activity in AD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imunoglobulina E
/
Biomarcadores
/
Selectina E
/
Células Endoteliais
/
Dermatite Atópica
/
Eosinófilos
/
Inflamação
/
Leucócitos
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Pediatric Allergy and Respiratory Disease
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS