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Effects of cold stress as a pathogenic factor on fatal disease progression of canine herpesvirus / 동물의과학연구지
Journal of Biomedical Research ; : 100-106, 2014.
Artigo em Inglês | WPRIM | ID: wpr-225639
ABSTRACT
Canine herpesvirus (CHV) is a member of the alphaherpesvirus subfamily, which can cause severe hemorrhagic diseases in neonatal pups as well as mild or subclinical respiratory infections in adult dogs. We examined the effects of cold stress on disease progression of CHV, an alphaherpesvirus, in neonatal puppies. Eight puppies were challenged intranasally with CHV suspension and divided into a cold stress treatment group and a hyperthermal group. Four pups were left uninoculated as controls and divided into cold and hyperthermal groups. In the challenged cold treatment group, all pups showed CHV-related disease within 5 days; pathological changes were observed in organs of puppies showing clinical symptoms. Grossly, numerous petechial red foci were scattered throughout lungs, kidneys, livers, and intestines of all CHV-infected puppies exposed to cold stress. Most puppies showed typical clinical signs and macroscopic lesions, and CHV infection was confirmed by isolation of the virus. However, in the challenged hyperthermal group, only one of the pups showed mild symptoms of CHV-induced disease. None of the puppies in the uninoculated group showed abnormal signs, although they were exposed to cold stress. These findings indicate that cold stress can cause rapid disease progression of CHV, an alphaherpesvirus.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Infecções Respiratórias / Progressão da Doença / Hemorragia / Intestinos / Rim / Fígado / Pulmão Limite: Animais / Humanos Idioma: Inglês Revista: Journal of Biomedical Research Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Infecções Respiratórias / Progressão da Doença / Hemorragia / Intestinos / Rim / Fígado / Pulmão Limite: Animais / Humanos Idioma: Inglês Revista: Journal of Biomedical Research Ano de publicação: 2014 Tipo de documento: Artigo