A case of regression of atypical dense deposit disease without C3 deposition in a child / 소아과
Korean Journal of Pediatrics
; : 766-769, 2010.
Article
em En
| WPRIM
| ID: wpr-225655
Biblioteca responsável:
WPRO
ABSTRACT
Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10 years, approximately half of the affected patients progress to end-stage renal disease. We report a rare case of regressive DDD without C3 deposition after steroid therapy in an 11-year-old boy. The patient presented with edema, gross hematuria, and nephrotic-range proteinuria. Laboratory testing revealed a serum creatinine level of 1.17 mg/dL, albumin level of 2.3 g/dL, and serum C3 level of 125 mg/dL (range 90-180 mg/dL). The results of the renal biopsy were consistent with DDD without C3 deposition. After 6 weeks of steroid therapy, the nephrotic syndrome completely resolved. The follow-up renal biopsy showed a significant reduction in mesangial proliferation and disappearance of electron-dense deposits in the GBM.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteinúria
/
Biópsia
/
Indução de Remissão
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Glomerulonefrite Membranoproliferativa
/
Seguimentos
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Creatinina
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Diclorodifenildicloroetano
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Edema
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Membrana Basal Glomerular
/
Glomerulonefrite
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2010
Tipo de documento:
Article