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Is islet transplantation a realistic approach to curing diabetes?
The Korean Journal of Internal Medicine ; : 62-66, 2017.
Artigo em Inglês | WPRIM | ID: wpr-225713
ABSTRACT
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet transplantation is now indicated for more specific clinical benefits. With the long-awaited report of the first phase 3 clinical trial in 2016, allogeneic islet transplantation is now transitioning from an experimental to a proven therapy for type 1 diabetes with problematic hypoglycemia. Islet autotransplantation has already been therapeutically proven in chronic pancreatitis with severe abdominal pain refractory to conventional treatments, and it holds promise for preventing diabetes after partial pancreatectomy due to benign pancreatic tumors. Based on current evidence, this review focuses on islet transplantation as a realistic approach to treating diabetes.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pancreatectomia / Transplante Autólogo / Dor Abdominal / Transplante das Ilhotas Pancreáticas / Ilhotas Pancreáticas / Pancreatite Crônica / Autoenxertos / Hipoglicemia / Insulina Tipo de estudo: Guia de Prática Clínica Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Internal Medicine Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pancreatectomia / Transplante Autólogo / Dor Abdominal / Transplante das Ilhotas Pancreáticas / Ilhotas Pancreáticas / Pancreatite Crônica / Autoenxertos / Hipoglicemia / Insulina Tipo de estudo: Guia de Prática Clínica Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Internal Medicine Ano de publicação: 2017 Tipo de documento: Artigo