Osteopontin and Developing Kidney
Journal of the Korean Society of Pediatric Nephrology
; : 1-7, 2006.
Article
em En
| WPRIM
| ID: wpr-226655
Biblioteca responsável:
WPRO
ABSTRACT
Osteopontin (OPN) is a glycosylated phosphoprotein which mediates cell adhesion and migration, and is produced by bone, macrophages, endothelial cells, and epithelial cells. The many regulatory functions of OPN include bone remodeling, tumor invasion, wound repair, and promotion of cell survival. It is produced by renal tubular epithelial cells, and expression is upregulated in glomerulonephritis, hypertension, ischemic acute renal failure, renal ablation, and UUO. In this review, we discuss about osteopontin in general aspect, expression, role on the development and pathologic condition of neonatal kidney.
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Assunto principal:
Ferimentos e Lesões
/
Adesão Celular
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Sobrevivência Celular
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Remodelação Óssea
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Células Endoteliais
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Células Epiteliais
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Osteopontina
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Injúria Renal Aguda
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Glomerulonefrite
/
Hipertensão
Idioma:
En
Revista:
Journal of the Korean Society of Pediatric Nephrology
Ano de publicação:
2006
Tipo de documento:
Article