The Neutralizing Effect of Panax Ginseng for Toxicities in the Survival, Sperm Quality, Pregnancy and F1 Generation of Guinea Pigs Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin / 대한비뇨기과학회지
Korean Journal of Urology
;
: 161-168, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-227035
ABSTRACT
PURPOSE:
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), one of the most potent environmental pollutants, is known to disrupt the endocrine, immune, and reproductive system. This study was carried out to investigate the effect of a panax ginseng water extract (PG-WE) on the survival rate, sperm quality, and fertility impaired by TCDD. MATERIALS ANDMETHODS:
Eighty male guinea pigs were divided into 8 groups. The normal control group received the vehicle and saline. TCDD was intraperitoneally injected at a single dose of 1microgram/kg. A PG-WE was administered at 100 or 200mg/kg/ day 1wk prior to (P groups) or subsequent to (C groups) TCDD-exposure for 12 and 10 weeks, respectively. The G groups received the vehicle and the PG-WE of 100 or 200mg/kg/day, respectively. The parameters for the male guinea pigs were assessed for 40 weeks. The effects on the F1 generation were assessed at a growth period of F1.RESULTS:
All single TCDD-treated group animals died within 18 days and the survival rate of the PG-WE-treated groups increased in a dose dependant manner. Forty to 70% of the P and C groups survived until the 40th week and reached sexual maturation. The death rate of the progeny born from the PG-WE-treated groups was significantly lower than that in the NC group (14.3%). The M/F ratio of the F1 generation in the P and C groups had higher female birth ratio. The sperm number and morphology showed no significant differences among the groups. The PG-WE increased the sperm motility in the guinea pigs exposed to TCDD.CONCLUSIONS:
Panax ginseng is a useful agent that can neutralize endocrine disrupters and environmental pollutants, and help maintain a high sperm quality after a growth period.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Maturidade Sexual
/
Contagem de Espermatozoides
/
Motilidade dos Espermatozoides
/
Espermatozoides
/
Água
/
Taxa de Sobrevida
/
Mortalidade
/
Guiné
/
Parto
/
Poluentes Ambientais
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
/
Gravidez
País/Região como assunto:
África
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
2002
Tipo de documento:
Artigo
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