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A case of Stevens-Johnson syndrome caused by oxcarbazepine / 대한내과학회지
Korean Journal of Medicine ; : 586-590, 2006.
Artigo em Coreano | WPRIM | ID: wpr-227050
ABSTRACT
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenobarbital / Fenitoína / Pele / Carbamazepina / Síndrome de Stevens-Johnson / Anticonvulsivantes Limite: Idoso / Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenobarbital / Fenitoína / Pele / Carbamazepina / Síndrome de Stevens-Johnson / Anticonvulsivantes Limite: Idoso / Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2006 Tipo de documento: Artigo