Array-based Comparative Genomic Hybridization and Its Application to Cancer Genomes and Human Genetics
Journal of Lung Cancer
;
: 77-86, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-22732
ABSTRACT
Microarray comparative genomic hybridization (CGH) has proven to be a specific, sensitive, and rapid technique, with considerable advantages compared to other methods used for analysis of DNA copy number changes. Array CGH allows for the mapping of genomic copy number alterations at the sub-microspecific level, thereby directly linking disease phenotypes to gene dosage alterations. The whole human genome can be scanned for deletions and duplications at over 30,000 loci simultaneously by array CGH (~40 kb resolution). Array CGH can be used for analysis of DNA copy number aberrations that cause not only cancer and human genetic disease, but also normal human variation. This review gives the various array CGH platforms and their applications in cancer and human genetics.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
DNA
/
Genoma Humano
/
Genoma
/
Dosagem de Genes
/
Complexo I de Proteína do Envoltório
/
Hibridização Genômica Comparativa
/
Variações do Número de Cópias de DNA
/
Genética Médica
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Lung Cancer
Ano de publicação:
2011
Tipo de documento:
Artigo
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