Changes in biochemical markers of bone turnover and bone mineral density during pregnancy and postpartum in korean women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 166-179, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-227847
ABSTRACT
OBJECTIVE:
To show the patterns of changes in biochemical markers of bone turnover and ultrasound bone mineral density (BMD) during pregnancy and postpartum in Korean women.METHODS:
We conducted a prospective study between February 2004 and February 2005. Forty-one healthy singleton pregnant women were included. We used quantitative ultrasonography for BMD measurement which is advantageous to pregnant women because it is radiation-free and it provides very accurate BMD that correlates highly with BMD measured by conventional dual energy x-ray absorptiometry. We measured marker of bone resorption (beta-Crosslaps), bone formation [total alkaline phosphatase (ALP), osteocalcin (OC)], total calcium, phosphorus and parathyroid hormone (PTH) during and after pregnancy.RESULTS:
During pregnancy, BMD slightly decreased in the third trimester. Bone resorption marker (beta-Crosslaps) increased steadily during pregnancy and immediate postpartum. Markers of bone formation (ALP, osteocalcin) increased from late pregnancy. Total calcium decreased slightly as bone resorption peaks in second trimester. PTH and phosphorus increased steadily throughout pregnancy and postpartum.CONCLUSION:
Pregnancy is characterized by high bone turnover in Korean women with resorption preceding formation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Hormônio Paratireóideo
/
Fósforo
/
Segundo Trimestre da Gravidez
/
Terceiro Trimestre da Gravidez
/
Reabsorção Óssea
/
Biomarcadores
/
Absorciometria de Fóton
/
Densidade Óssea
/
Osteocalcina
Tipo de estudo:
Estudo observacional
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2009
Tipo de documento:
Artigo
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