Your browser doesn't support javascript.
loading
Pyroninophilic Granules in Liver Cells of the Mice Treated with Alpha-Tocopherol and Thioacetamide
Yonsei Medical Journal ; : 40-49, 1972.
Artigo em Inglês | WPRIM | ID: wpr-227926
ABSTRACT
In an attempt to clarify the protective action of an antioxidant agent against acute toxicity of thioacetamide (TAA) and in order to throw some light on an satisfying concept of the mechanism of its action, a single dose of alphatocopherol (200 mg per kg) was given orally by stomch tube to male mice prior to the administration of thioacetamide in a dose of 200 mg per kg of body weight. Sections of liver samples, obtained from the mice which were sacrificed at intervals of 3, 6, 9, or 12 hours after TAA administration, were stained using the methyl green-pyronin technique. At 3 hours following TAA administration, the pretreatment with alpha-tocopherol inhibited almost completely such alterations of the hepatocytes in the animals given TAA alone, as revealed by loss and clumping of cytoplasmic pyroninophilic granules in the periportal zone of the lobule. At 6, 9, and l2 hours, the prevention of alpha-tocopherol was incomplete in degree and extent. The changes of the hepatocytes were more intense and extensive in the TAA-treated 6 to 12 hour-groups than in the 3 hour-group of TAA-treated ones. Some discussion is given of the mechanism of TAA toxicity, with respect to the microsoma1 lipid peroxidation.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina E / Doença Hepática Induzida por Substâncias e Drogas / Fígado / Animais / Acetamidas Limite: Animais Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1972 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina E / Doença Hepática Induzida por Substâncias e Drogas / Fígado / Animais / Acetamidas Limite: Animais Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1972 Tipo de documento: Artigo