Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues
Journal of Korean Medical Science
;
: 313-316, 2001.
Artigo
em Inglês
| WPRIM
| ID: wpr-228346
ABSTRACT
The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estômago
/
Tiroxina
/
Álcool Desidrogenase
/
Tireotoxicose
/
Ratos Sprague-Dawley
/
Mucosa Gástrica
/
Rim
/
Fígado
/
Pulmão
/
Animais
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2001
Tipo de documento:
Artigo
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