Biomedical significance of endothelial cell specific growth factor, angiopoietin
Experimental & Molecular Medicine
;
: 1-11, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-228523
ABSTRACT
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth factors (FGFs), platelet-derived growth factor, or transforming growth factor-beta, had profound effects in endothelial cells. But such factors were nonspecific, in that they could act on many other cells, and it seemed unlikely that these growth factors would be effective targets for treatment of endothelial cell diseases. A recently discovered endothelial cell specific growth factor, angiopoietin, has greatly contributed to our understanding of the development, physiology, and pathology of endothelial cells (Davis et al., 1996; Yancopoulos et al., 2000). The recent studies that identified and characterized the physiological and pathological roles of angiopoietin have allowed us to widen and deepen our knowledge about blood vessel formation and vascular endothelial function. Therefore, in this review, we describe the biomedical significance of these endothelial cell growth factors, the angiopoietins, in the vascular system under normal and pathological states.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema Urogenital
/
Endotélio Vascular
/
Glicoproteínas de Membrana
/
Transdução de Sinais
/
Sobrevivência Celular
/
Fatores de Crescimento Endotelial
/
Linfocinas
/
Processamento Alternativo
/
Neovascularização Fisiológica
/
Peptídeos e Proteínas de Sinalização Intercelular
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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