Chronic Central Serous Chorioretinopathy: Photodynamic Therapy

ABSTRACT

PURPOSE: To evaluate the clinical results of photodynamic therapy (PDT) using verteporfin in patients with chronic central serous chorioretinopathy (CSC). METHODS: A retrospective study in a clinical practice setting of eight eyes (eight patients) with chronic CSC. The point of dye leakage on the fluorescein angiogram (FA) was too close to the fovea to treat these patients with focal laser treatment. Additionally, choroidal vascular hyperpermeability was observed with indocyanine green angiogram (ICGA). Patients were treated with verteporfin PDT and evaluated for visual acuity, complications, change in centralmacular thickness with the optical coherence tomogram (OCT), and recurrence. RESULTS: Pre-PDT visual acuity improved from 0.46 (0.04~0.7) to 0.82 (0.15~1.2) with an average of 15.2 months follow-up post-treatment (p=0.011). The mean central macular thickness also reduced from 283 micrometer to 135.5 micrometer. Central macular exudation resolved completely in all eyes. There was no recurrence after PDT. CONCLUSIONS: PDT with verteporfin appeared to be a beneficial treatment option for patients with chronic CSC.