Effect of Tamoxifen in C6 Glioma Cells
Journal of Korean Neurosurgical Society
;
: 5-10, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-228730
ABSTRACT
This work describes tamaoxifen, a nonsteroidal antiestrogen compound, which has been used extensively in the treatment of breast cancer on account of its efficacy and relatively low toxicity. It has been reported to inhibit glioma proliferation in all cell line tested, acting by a mechanism independent of estrogen receptor blockade. Tamoxifen causes cytotoxicity at higher concentration(>or=5 micrometer), as compared with control. Our results showed that this compound decreased the rate of cell proliferation in dose-dependent manner. Its treatment against the C6 glioma cells also resulted in enhancement of the antitumor effect. These data suggest that tamoxifen may serve as an useful agent in chemotherapy of glioma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamoxifeno
/
Neoplasias da Mama
/
Linhagem Celular
/
Moduladores de Receptor Estrogênico
/
Proliferação de Células
/
Tratamento Farmacológico
/
Estrogênios
/
Glioma
Idioma:
Coreano
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
1997
Tipo de documento:
Artigo
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