A Direct Inhibitory Effect of Botulinum Toxin Type A on Antral Circular Muscle Contractility of Guinea Pig
Yonsei Medical Journal
;
: 968-973, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-228774
ABSTRACT
PURPOSE:
Recent studies suggest new mechanisms of Botulinum toxin (BoNT) other than inhibiting acetylcholine (ACh) release from nerve terminals. The aim of this study was to determine whether other mechanisms for BoNT exist, so that it directly inhibits smooth muscle contraction. MATERIALS ANDMETHODS:
Guinea pig antral muscle strips were studied in vitro after 2 hours of exposure to Botulinum toxin type A (BoNT/A). Contractile responses to electric field stimulation (EFS), high K+ (60 mM) and ACh (100 microM) were evaluated 24 and 48 hours after antral intramuscular injection of BoNT/A or vehicle.RESULTS:
BoNT/A inhibited muscular contraction caused by high K+ and ACh. Contractile responses to low (1 & 4 Hz) and high (8 & 20 Hz) frequency EFS of antral muscle strips 24 and 48 hours after antral intramuscular injection of BoNT/A were significantly inhibited.CONCLUSION:
The ability of BoNT/A to directly inhibit antral muscular contractility suggests a new mechanism for the pharmacologic actions of BoNT-direct inhibition of muscular contraction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antro Pilórico
/
Técnicas In Vitro
/
Toxinas Botulínicas
/
Acetilcolina
/
Guiné
/
Toxinas Botulínicas Tipo A
/
Ações Farmacológicas
/
Cobaias
/
Injeções Intramusculares
/
Contração Muscular
Limite:
Animais
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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