Correlation of DEFA1 Gene Copy Number Variation with Intestinal Involvement in Behcet's Disease
Journal of Korean Medical Science
; : 107-109, 2012.
Article
em En
| WPRIM
| ID: wpr-228910
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WPRO
ABSTRACT
Copy number variation has been associated with various autoimmune diseases. We investigated the copy number (CN) of the DEFA1 gene encoding alpha-defensin-1 in samples from Korean individuals with Behcet's disease (BD) compared to healthy controls (HC). We recruited 55 BD patients and 35 HC. A duplex Taqman(R) real-time PCR assay was used to assess CN. Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 +/- 0.2. There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. Variable DEFA1 gene CNs were observed in both BD patients and HC and a high DEFA1 gene CN may be associated with susceptibility to intestinal involvement in BD.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Síndrome de Behçet
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Dosagem de Genes
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Predisposição Genética para Doença
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Alfa-Defensinas
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Reação em Cadeia da Polimerase em Tempo Real
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Genótipo
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Enteropatias
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2012
Tipo de documento:
Article