A Case of Splenectomy in a Patient with Refractory Thrombotic Thrombocytopenic Purpura / 대한신장학회지
Korean Journal of Nephrology
;
: 243-247, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-229129
ABSTRACT
The introduction of plasma exchange has significantly improved the outcome of thrombotic thrombocytopenic purpura (TTP) and the survival rate was increased from 10 to 80-90%. TTP refractory to plasma exchange therapy, however, is still a therapeutic challenge. We describe here a patient who partially responded to plasma exchange therapy, but remained dependent on plasma infusions. To discontinue plasma therapy, several attempts using agents such as rituximab, vincristine, and cyclosporine A had been tried, but all failed. After splenectomy, serum LDH and blood platelet count were normalized. Plasmapheresis were we able to discontinue after 2 weeks of splenectomy. Steroid and cyclosporine were tapered off after 3 months and 5 months after splenectomy respectively, and the patient has been staying in remission ever since. We suggest that splenectomy is a worthwhile treatment option in patients with refractory TTP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Troca Plasmática
/
Contagem de Plaquetas
/
Púrpura Trombocitopênica Trombótica
/
Esplenectomia
/
Nucleotídeos de Timina
/
Vincristina
/
Taxa de Sobrevida
/
Plasmaferese
/
Ciclosporina
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2008
Tipo de documento:
Artigo
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