Haplotype Phylogeny of a 200kb Region in the Human Chromosome X Terminal Band (q28)
Genomics & Informatics
;
: 130-135, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-22936
ABSTRACT
The haplotypes of a 200 kb region in the human chromosome X terminal band (q28) were analyzed using the International HapMap Project PhaseII data, which had been collected for three analysis panels (YRI, CEU, and CHB+JPT). When multiple linkage disequilibrium blocks were encountered for a panel, the neighboring haplotypes that had crossover rate of 5% or more in the panel were combined to generate 'haploid' configurations. This resulted in 8, 7, and 5 'haploid' configurations for the panels of YRI, CEU, and CHB+JPT, respectively. The multiple sequence alignment of these 'haploids' was used for the calculation of allele-sharing distances and the subsequent principal coordinate analysis. Two 'haploids' in CEU and CHB+JPT were hypothesized as 'parental' in light of the observations that the successive recombinants of these haploids can model two other haploids in CEU and CHB+JPT, and that their configurations were consistent with those in YRI. This study demonstrates the utility of haplotype phylogeny in understanding population evolution.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Haplótipos
/
Desequilíbrio de Ligação
/
Alinhamento de Sequência
/
Cromossomos Humanos
/
Projeto HapMap
/
Haploidia
/
Luz
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2008
Tipo de documento:
Artigo
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