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Second trimester prenatal screening for Down's syndrome in Mainland Chinese subjects using double-marker analysis of α-fetoprotein and β-human chorionic gonadotropin combined with measurement of nuchal fold thickness
Annals of the Academy of Medicine, Singapore ; : 315-318, 2011.
Artigo em Inglês | WPRIM | ID: wpr-229662
ABSTRACT
<p><b>INTRODUCTION</b>This study examines the effectiveness of double-marker analysis for α-fetoprotein (AFP) and β-human chorionic gonadotropin (β-hCG) combined with measurement of nuchal fold thickness (NT) in the detection of Down's syndrome (DS) in Mainland Chinese subjects during second trimester prenatal screening.</p><p><b>MATERIALS AND METHODS</b>We examined pregnant women with a singleton pregnancy between 15 and 21 weeks of gestation who underwent second trimester screening for DS using double-marker analysis for AFP and β-hCG combined with ultrasound measurement of NT. The combined risk of DS was calculated. A cut-off of 1/270 was used to define a pregnancy at high-risk of DS. Amniocentesis was offered to all patients with high-risk pregnancies.</p><p><b>RESULTS</b>Using double-marker analysis for AFP and β-hCG in combination with measurement of NT, the detection rate of DS increased from 66.7% to 77.8% when compared with double-marker analysis alone with similar false-positive rates (4.35%, 4.83% respectively). Using receiver operating characteristic curve (ROC) analysis, we determined that the double-marker analysis combined with measurement of NT exhibited an increased area under the curve (AUC) of 0.835 (95% CI 0.743 to 0.927) when compared to double-marker analysis alone, which had an AUC of 0.748 (95% CI 0.635 to 0.860). In addition, both methods were more effective than any other single test such as AFP, free β-hCG or NT measurement.</p><p><b>CONCLUSION</b>Second trimester prenatal screening using double-marker analysis for AFP and β-hCG combined with measurement of NT is effective for the detection of DS in Mainland Chinese pregnancies.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Segundo Trimestre da Gravidez / Diagnóstico Pré-Natal / Sangue / Diagnóstico por Imagem / Biomarcadores / Alfa-Fetoproteínas / China / Programas de Rastreamento / Idade Gestacional / Síndrome de Down Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Adulto / Feminino / Humanos / Gravidez País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of the Academy of Medicine, Singapore Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Segundo Trimestre da Gravidez / Diagnóstico Pré-Natal / Sangue / Diagnóstico por Imagem / Biomarcadores / Alfa-Fetoproteínas / China / Programas de Rastreamento / Idade Gestacional / Síndrome de Down Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Adulto / Feminino / Humanos / Gravidez País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of the Academy of Medicine, Singapore Ano de publicação: 2011 Tipo de documento: Artigo