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Effects of terephthalic acid on rat lipid metabolism / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 273-276, 2006.
Artigo em Inglês | WPRIM | ID: wpr-229689
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of terephthalic acid (TPA) on lipid metabolism in Sprague-Dawley (SD) rats.</p><p><b>METHODS</b>Five groups of SD rats that ingested 0%, 0.04%, 0.2%, 1%, and 5% TPA, respectively, were included in a 90-day subchronic feeding study. Effects of TPA on levels of serum protein, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), total antioxidative capability (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA) were observed. Urine samples were collected and analyzed for concentration of ion.</p><p><b>RESULTS</b>TPA decreased the level of serum T-AOC in a dose dependent manner. The contents of serum and bladder MDA significantly decreased in 1% and 5% TPA ingestion groups. Serum CuZn superoxide dismutase (CuZnSOD) lowered in groups of 0.2%, 1%, and 5% TPA. TPA subchronic feeding had no significant influences on serum TC, LDL or HDL, but increased serum TG, TP and ALB after administration of 0.04% and/or 0.2% TPA. Concentrations of urinary Ca2+, Mg2+, Na+, and K+ were elevated in 1% and 5% TPA groups.</p><p><b>CONCLUSION</b>Antioxidative potential decreased after TPA exposure. MDA increase in serum and bladder tissues was one of the most important reactions in rats which could protect themselves against TPA impairment. The decrease of serum CuZnSOD was related to the excretion of Zn2+.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ácidos Ftálicos / Triglicerídeos / Urina / Sangue / Proteínas Sanguíneas / Aumento de Peso / Colesterol / Ratos Sprague-Dawley / Superóxidos / Metabolismo dos Lipídeos Limite: Animais Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ácidos Ftálicos / Triglicerídeos / Urina / Sangue / Proteínas Sanguíneas / Aumento de Peso / Colesterol / Ratos Sprague-Dawley / Superóxidos / Metabolismo dos Lipídeos Limite: Animais Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2006 Tipo de documento: Artigo