Potential association of lead exposure during early development of mice with alteration of hippocampus nitric oxide levels and learning memory / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 375-378, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-229740
ABSTRACT
<p><b>OBJECTIVE</b>Chronic lead (Pb) exposure during development is known to produce learning deficits. Nitric oxide participates in the synaptic mechanisms involved in certain forms of learning and memory. This study was designed to clarify whether Pb-induced impairment in learning and memory was associated with the changes of nitric oxide levels in mice brains.</p><p><b>METHODS</b>Sixty Balb/c mice aged 10 days were chosen. A model of lead exposure was established by drinking 0.025%, 0.05%, 0.075% lead acetate, respectively for 8 weeks. The controls were orally given distilled water. The ability to learn and memorize was examined by open field test, T-water maze test. In parallel with the behavioral data, NO level of hippocampus tissue was detected by biochemical assay.</p><p><b>RESULTS</b>Compared with control groups, (1) the weight of 0.075% group was significantly reduced (P<0.05); (2) The number of times in mice attaining the required standards in T-water maze test was lower in 0.075% group (P<0.01). No significant difference was found between experimental and control groups in open field test (P>0.05); (3) NO level of mouse hippocampus tissue was decreased in 0.075% group (P<0.01).</p><p><b>CONCLUSIONS</b>The findings suggest that decreased hippocampus NO level may contribute to the Pb-induced deficits in learning and memory processes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Compostos Organometálicos
/
Fisiologia
/
Redução de Peso
/
Relação Dose-Resposta a Droga
/
Toxicidade
/
Hipocampo
/
Memória
/
Metabolismo
/
Camundongos Endogâmicos BALB C
/
Óxido Nítrico
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2005
Tipo de documento:
Artigo
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