Study on the expression of survivin mRNA and protein in nasopharyngeal carcinoma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 179-182, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-229796
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between survivin mRNA and protein expression and nasopharyngeal carcinoma (NPC).</p><p><b>METHODS</b>Survivin mRNA and protein were detected by in situ hybridization and immunohistochemical S-P staining respectively.</p><p><b>RESULTS</b>Among 64 cases of NPC, 42 cases (65.6%) were positive for survivin mRNA expression, 30 cases (46.9%) had high expression level. In 46 cases (71.9%) of NPC were positive for survivin protein expression, and 38 cases (59.4%) had high expression level. In 22 cases of NPC with detailed clinical information, the positive expression rates of survivin mRNA and protein in stages III+ IV of NPC were 66.7% and 61.1% respectively, which were higher than those in stages I+ II of NPC (50.0% and 50.0% respectively). There was no significant difference between survivin mRNA and protein expression regarding age or gender of NPC patients (all P> 0.05). The positive expression rates of survivin mRNA and protein in chronic nasopharyngitis group were 33.3% and 23.3% respectively, which were lower than those in NPC group (chi (2)= 12.04, P< 0.01 and chi (2)= 19.57, P< 0.01, respectively). In 64 cases of NPC, 36 cases were positive for both survivin mRNA and protein, and the expression of survivin mRNA and protein showed positive correlation (phi = 0.43).</p><p><b>CONCLUSION</b>The expression of survivin gene may play some roles in the pathogenesis of NPC. Detection of survivin mRNA and protein will be helpful for diagnosis, clinical staging and prognosis of NPC.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imuno-Histoquímica
/
Carcinoma
/
Regulação Neoplásica da Expressão Gênica
/
Fatores Sexuais
/
Neoplasias Nasofaríngeas
/
Fatores Etários
/
Hibridização In Situ
/
Proteínas Inibidoras de Apoptose
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2008
Tipo de documento:
Artigo
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