Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association of thiazide-sensitive Na+ -Cl* cotransporter (TSC) gene 1784C/T and 2736G/A polymorphisms with the risk of essential hypertension (EH) in a Han nationality population.</p><p><b>METHODS</b>A community-based, case-control study including 190 EH patients and 94 sex- and age-matched controls was conducted. Genotypes of TSC gene 1784C/T and 2736G/A polymorphisms were analyzed by gene chip technology.</p><p><b>RESULTS</b>The genotype (1784C/T CC, CT, TT87, 88, 15 vs 36, 52, 6û2736G/A GG, AG, AA167, 22, 1 vs 83, 10, 1) and alleles frequency (1784C/T C, T68.9%, 31.1% vs 66.0%, 34.0%; 2736G/A G,A93.7%, 6.3% vs 93.6%, 6.4%) distribution of 1784C/T and 2736G/A showed no significant difference between the EH group and the control group (P >0.05). Moreover, no significant difference was observed in the frequencies distribution of four haplotypes (P > 0.05); Logistic regression analysis of haplotypes showed that the risk of EH had no significant difference in the population with different haplotypes (P > 0.05).</p><p><b>CONCLUSION</b>The 1784C/T and 2736G/A polymorphisms of TSC gene may not play an important role in the etiology of EH in a Han nationality population. The studies in the future are warranted to validate our findings.</p>