Association of APOA5 gene polymorphism with levels of lipids and atherosclerotic cerebral infarction in Chinese / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 576-578, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-229867
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the polymorphism of apolipoprotein A5 gene (APOA5) -12238 T>C and atherosclerotic cerebral infarction (ACI).</p><p><b>METHODS</b>Three hundred and forty-one subjects (170 ACI patients and 171 healthy controls) were collected to determine the genotypes by using polymerase chain reaction-restriction fragment length polymorphisms.</p><p><b>RESULTS</b>APOA5 allele frequencies of T/C were 0.588/0.412 and 0.424/0.576 in ACI group and control group respectively. There was significant difference in allele and genotype frequencies between ACI group and control group (P < 0.05). The levels of plasma triglyceride in ACI patients with TT genotype were higher than those in patients with CC genotypes (P < 0.05).</p><p><b>CONCLUSION</b>The relationship is found between the site of APOA5 gene -12238 T>C and ACI. There is a significant correlation between TT genotype of APOA5 and the levels of plasma triglyceride in patients with ACI.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apolipoproteínas A
/
Polimorfismo Genético
/
Sangue
/
Polimorfismo de Fragmento de Restrição
/
Estudos de Casos e Controles
/
Arteriosclerose Intracraniana
/
Infarto Cerebral
/
Reação em Cadeia da Polimerase
/
Povo Asiático
/
Apolipoproteína A-V
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2007
Tipo de documento:
Artigo
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