Study on T13254C polymorphism of the platelet membrane glycoprotein VI in Chinese Han population / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 140-143, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-229882
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the T13254C polymorphism frequency in GPVI gene among Chinese Han population and its relevance to the arterial thrombotic diseases.</p><p><b>METHODS</b>The enrolled population in this study consisted of 314 healthy subjects and 274 patients with myocardial or cerebral infarctions. GPVI T13254C genotypes were determined by PCR amplification of a 355 bp fragment encompassing exon 5 of GPVI gene, followed by Msp I digestion of the product. The digested products were analyzed in 15% polyacrylamide gel electrophoresis (PAGE).</p><p><b>RESULTS</b>The frequencies of the T allele and C allele in the T13254C polymorphism were 0.9809 and 0.0191, respectively, with a frequency of heterozygous of 0.0319, which were significantly different from those reported in western population (P < 0.01). As compared with controls, no significant difference in T13254C genotype distribution was found in the arterial thrombotic diseases group.</p><p><b>CONCLUSION</b>The GPVI T13254C polymorphism appears in a low frequency in Chinese Han population. No relationship is found between T13254C polymorphism and the risk for thrombotic diseases.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dados de Sequência Molecular
/
Sequência de Bases
/
Glicoproteínas da Membrana de Plaquetas
/
China
/
Infarto Encefálico
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alelos
/
Etnologia
/
Frequência do Gene
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2005
Tipo de documento:
Artigo
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