Identification of binding proteins to the PDZ domain of ERBIN / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To identify the binding proteins to PDZ domain of ERBIN.</p><p><b>METHODS</b>Using PDZ domain of ERBIN as the bait, yeast two-hybrid technology was employed to screen the human lymphocyte leukemia cells MATCHMAKER cDNA library. The protein interaction was identified by immunoprecipitation.</p><p><b>RESULTS</b>A PDZ-binding protein, TAX1, was identified.</p><p><b>CONCLUSION</b>TAX1 is a novel binding protein to PDZ domain of ERBIN.</p>