Effect of tacrolimus on the growth cycle of murine hair follicles / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 209-212, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-230002
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of tacrolimus on murine hair follicle cycle.</p><p><b>METHOD</b>Hematoxylin-eosin dyeing and reverse transcription-polymerase chain raction techniques were used.</p><p><b>RESULTS</b>Five days after depilation, the hair follicles in both the tacrolimus group and the minoxidil group was in anagen V, while that in the vaseline group was in anagen III. vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were detected in back skin in both the tacrolimus group and the minoxidil group, but not in the vaseline group.</p><p><b>CONCLUSION</b>Tacrolimus can promote the growth of hair by stimulating the hair follicle to enter anagen V in mice, which may be explained by the effects of VEGF and HGF.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Pele
/
Tacrolimo
/
Fator de Crescimento de Hepatócito
/
Folículo Piloso
/
Fator A de Crescimento do Endotélio Vascular
/
Metabolismo
/
Camundongos Endogâmicos C57BL
/
Minoxidil
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS