A Study of Altered Cell-Mediated Immunity in Peritoneal Fluid of Patients with Endometriosis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1965-1971, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-23049
ABSTRACT
OBJECTIVE:
Our purpose was to investigate the relationship between the levels of IL-6 and tumor necrosis factor-alpha in the peritoneal fluid(PF) of women with and without endometriosis and infertile women.Design:
Prospective and case-control study.Setting:
University hospital. Patients Twenty-nine women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and twenty-eight women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Main OutcomeMeasures:
PF IL-6 and tumor necrosis factor-alpha levels were determined using commercial ELISA. IL-6 and tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and with infertile and fertile women, and then also compared according the revised American Fertility Society classification.RESULTS:
IL-6 and tumor necrosis factor-alpha concentrations were higher than in the PF of women with endometriosis than in matched normal controls. Cyclic variations in IL-6 concentrations were seen in PF from patients with endometriosis the concentrations in the secretory phase were significantly higher than those in the proliferative phase. IL-6 concentrations were higher than in the PF among of infertile women than in fertile women. A significant correlation between PF IL-6 and tumor necrosis factor-alpha concentrations and endometriosis stage III and IV was noted.CONCLUSIONS:
Increased PF levels of IL-6 and tumor necrosis factor-alpha in patients with endometriosis may be relate to endometriosis-associated infertility and to the pathogenesis of endometriosis suggesting that partially contribute to the disturbed immune regulation observed in patients with endometriosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Líquido Ascítico
/
Ensaio de Imunoadsorção Enzimática
/
Estudos de Casos e Controles
/
Estudos Prospectivos
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Classificação
/
Avaliação de Resultados em Cuidados de Saúde
/
Endometriose
/
Fertilidade
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
1999
Tipo de documento:
Artigo
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