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A Study of Altered Cell-Mediated Immunity in Peritoneal Fluid of Patients with Endometriosis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 1965-1971, 1999.
Artigo em Coreano | WPRIM | ID: wpr-23049
ABSTRACT

OBJECTIVE:

Our purpose was to investigate the relationship between the levels of IL-6 and tumor necrosis factor-alpha in the peritoneal fluid(PF) of women with and without endometriosis and infertile women.

Design:

Prospective and case-control study.

Setting:

University hospital. Patients Twenty-nine women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and twenty-eight women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Main Outcome

Measures:

PF IL-6 and tumor necrosis factor-alpha levels were determined using commercial ELISA. IL-6 and tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and with infertile and fertile women, and then also compared according the revised American Fertility Society classification.

RESULTS:

IL-6 and tumor necrosis factor-alpha concentrations were higher than in the PF of women with endometriosis than in matched normal controls. Cyclic variations in IL-6 concentrations were seen in PF from patients with endometriosis the concentrations in the secretory phase were significantly higher than those in the proliferative phase. IL-6 concentrations were higher than in the PF among of infertile women than in fertile women. A significant correlation between PF IL-6 and tumor necrosis factor-alpha concentrations and endometriosis stage III and IV was noted.

CONCLUSIONS:

Increased PF levels of IL-6 and tumor necrosis factor-alpha in patients with endometriosis may be relate to endometriosis-associated infertility and to the pathogenesis of endometriosis suggesting that partially contribute to the disturbed immune regulation observed in patients with endometriosis.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Líquido Ascítico / Ensaio de Imunoadsorção Enzimática / Estudos de Casos e Controles / Estudos Prospectivos / Interleucina-6 / Fator de Necrose Tumoral alfa / Classificação / Avaliação de Resultados em Cuidados de Saúde / Endometriose / Fertilidade Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Líquido Ascítico / Ensaio de Imunoadsorção Enzimática / Estudos de Casos e Controles / Estudos Prospectivos / Interleucina-6 / Fator de Necrose Tumoral alfa / Classificação / Avaliação de Resultados em Cuidados de Saúde / Endometriose / Fertilidade Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 1999 Tipo de documento: Artigo