Determination of serum argininosuccinate lyase in diagnosing liver diseases / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 521-524, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-230548
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the value of the determination of the levels of serum argininosuccinate lyase (ASL) in diagnosing various liver diseases.</p><p><b>METHODS</b>Two hundred and ninety-one patients with various liver diseases, 257 patients with non-liver disease, and 32 healthy controls were recruited for this study and their serum ASL, ALT, AST, GGT, LDH, ALP, and total bilirubin (TBil) levels were determined. Liver biopsies were performed on 31 patients with hepatopathy.</p><p><b>RESULTS</b>Receiver operating characteristic (ROC) curve analysis showed that the sensitivity and specificity of ASL in assessing liver diseases were 100% and 91.1% (at cut-off values of 8 U/L), those of ALT were 97.6% and 24.7% and those of AST were 83.8% and 28.3% (both at cut-off values = 40.0 U/L), respectively. The levels of ASL in various liver disease patients were in liver cancer - acute hepatitis - liver cirrhosis - chronic hepatitis. A positive correlation (r = 0.417) was observed between serum ASL levels (86.9+/-26.5) and scores of histopathological inflammation grading (9.83+/-3.36).</p><p><b>CONCLUSION</b>ASL is of higher sensitivity and specificity than those of ALT and AST for diagnosing liver diseases. ASL may be used as a useful marker in estimating hepatopathy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Argininossuccinato Liase
/
Automação
/
Sangue
/
Química
/
Curva ROC
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Sensibilidade e Especificidade
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Soro
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Diagnóstico
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Hepatopatias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2007
Tipo de documento:
Artigo
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