A study of CXCR4/SDF-1 in hepatocellular carcinoma and liver cirrhosis / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 276-278, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-230624
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of stromal cell-derived factor-1 (SDF-1) and CX chemokine receptor-4 (CXCR-4) in patients with hepatocellular carcinoma (HC) and liver cirrhosis.</p><p><b>METHODS</b>Peripheral blood and/or ascites fluid were collected from 39 hepatocellular carcinoma patients, 16 patients with liver cirrhosis, 12 with hepatitis and 12 healthy donors. The SDF-1 expression was assayed by ELISA and CXCR-4 was measured by immunohistochemical methods.</p><p><b>RESULTS</b>The level of SDF-1 expression in the carcinoma patients was higher than that of the liver cirrhosis, hepatitis patients and healthy donors, but there was no significant difference between those of the healthy donors and hepatitis patients or liver cirrhosis patients. The levels of CXCR-4 expression were closely related to the tumor differentiation.</p><p><b>CONCLUSION</b>The expression of SDF-1 in the peripheral blood and the CXCR4 expression in the HCC tissues of the HC patients may be regarded as markers of HC and they may have a positive relationship with the differentiation and metastasis of HC.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Estudos de Casos e Controles
/
Carcinoma Hepatocelular
/
Receptores CXCR4
/
Quimiocina CXCL12
/
Cirrose Hepática
/
Metabolismo
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS