G894T mutation of the endothelial nitric oxide synthase gene in Chinese Han nationality / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 415-426, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-231034
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of G894T mutation of the endothelial nitric oxide synthase (eNOS) gene in Chinese Han nationality.</p><p><b>METHODS</b>G894T mutation of the eNOS gene of 108 unrelated healthy individuals was studied by means of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis.</p><p><b>RESULT</b>All subjects were genotyped for eNOS gene; the frequencies of the GG, GT and TT genotypes were 0.9095, 0.0883 and 0.0021, respectively. In the Han nationality, the frequency of the GT, TT genotypes was lower than that in Japanese and Caucasian of UK (P< 0.05).</p><p><b>CONCLUSION</b>These results suggest that there are significant differences in G894T mutation of eNOS gene between the Chinese Han nationality and other ethnic populations.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
China
/
Reação em Cadeia da Polimerase
/
Óxido Nítrico Sintase
/
Povo Asiático
/
Óxido Nítrico Sintase Tipo III
/
Etnologia
/
Genética
/
Genótipo
/
Mutação
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2003
Tipo de documento:
Artigo
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