Improved method of epalrestat synthesis / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To synthesize epalrestat and to improve the method of synthesis.</p><p><b>METHODS</b>Glycine reacted with carbondisulfide,then with ClCH(2)COONa to give 3-carboxymethylrhodanine. PhCHO reacted with CH(3)CH(2)CHO in NaOH/EtOH solution to produce 2-methylcinnamaldehyde.3-carboxymethylrhodanine and 2-methylcinnamaldehyde were treated with NH(3).H(2)O to obtain epalrestat.</p><p><b>RESULT</b>The described method was effective in synthesis of Epalrestat and the yield was higher than that of in references.</p><p><b>CONCLUSION</b>The results suggest that this method is suitable for industrial production.</p>