Analysis of TSH screening results of 42,979 newborns in Zhejiang Province / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>Document the prevalence of congenital hypothyroidism in Zhejiang Province, by neonatal screening of TSH.</p><p><b>METHODS</b>DELFIA neonatal TSH kit was applied for the quantitative determination of thyrotropin in blood specimens dried on filter paper.</p><p><b>RESULT</b>Among the 42 979 newborns, 112 had elevated hTSH concentration in blood. All had T3, T4 and TSH concentrations measured in serum and 29 were diagnosed as congenital hypothyroidism. The diagnosis time was 13 to 59 days and mean time was (27.9+/-9.2) days.</p><p><b>CONCLUSION</b>The incidence of congenital hypothyroidism in Zhejiang Province is not low. The TSH screening in newborns is significant in eugenics and the improvement of population quality.</p>