Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 279-291, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-231067
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of very late antigen(VLA) antagonist BIO-1211 on eosinophil chemotaxis, recruitment and mediator release.</p><p><b>METHODS</b>Eosinophil chemotaxis was induced by platelet activating factor(PAF) in vitro and eosinophil recruitment and release were determined in vivo.</p><p><b>RESULT</b>VLA antagonist BIO-1211 inhibited eosinophil chemotaxis induced by PAF. The inhibitory rates at 4x10(-11), 4x10(-10), 4x10(-9) mol x L(-1) were 24.9%, 29.9%, and 31.3%, respectively. Pretreatment by BIO-1211 1, 3 and 10 mg x kg(-1) intraperitoneally inhibited the recruitment of eosinophils in PAF in the rat induced by Sephadex in a dose dependent manner. Inhibitory rates were 60.3%, 68.9%, and 72.9%(P<0.05), respectively. BIO-1211 did not inhibit eosinophil peroxidase(EPO) release from eosinophils.</p><p><b>CONCLUSION</b>BIO-1211 inhibits eosinophil chemotaxis and recruitment, alleviates local inflammation, and may represent a new type of drug for allergic diseases.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligopeptídeos
/
Peroxidases
/
Farmacologia
/
Fisiologia
/
Fator de Ativação de Plaquetas
/
Movimento Celular
/
Quimiotaxia de Leucócito
/
Ratos Sprague-Dawley
/
Secreções Corporais
/
Integrina alfa4beta1
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2003
Tipo de documento:
Artigo
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